Correlation of TNF-α, IFN-γ and TGF-β Expression with In-vitro Fertilization Success Rates in Women with Recurrent Implantation Failure Undergoing Treatment with Intra-lipid Infusion

This study aimed at assessing the correlations between gene expression of TNF-α, IFN-γ, TGF-β in peripheral lymphocytes from women suffering repeated implantation failure before and after intravenous Intra-lipid (IL) therapy, correlation changes with IL infusion success rate IVF cycles. Twenty-three complaining unexplained infertility without history autoimmune disorders, or immunodeficient diseases were included. All included aged <40 years, BMI <28 recurrent cycles failure, seeking medical advice for new trial. average responders to induction ovulation (≥5 oocytes each cycle) good quality embryos transferred uterus proper time. Included received 200 ml 10% slowly intravenous. Two venous blood samples taken all candidates, one second was day embryo transfer. The current detected a significant reduction TNF-α increased TGF-β, while non-significant IFN-γ treatment. Significant associations positive clinical ongoing pregnancy observed, associated only pregnancy. In conclusion, therapy might have impact on rates via alterations cytokines mainly mRNA expression.